Vaccine Research Center

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Department of Health and Human Services

The National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center (VRC) conducts research that facilitates the development of effective vaccines and monoclonal antibodies for the prevention of infectious diseases, such as HIV, influenza, malaria, Zika, Ebola, and SARS-CoV-2. The VRC Clinical Trials Program (CTP) includes clinicians, protocol specialists, research nurses, study coordinators, data specialists, and other support staff. The CTP conducts proof-of-concept, phase 1 clinical research studies to assess the safety and immunogenicity of first-in-human vaccines and monoclonal antibodies. The CTP is comprised of approximately 50 people and initiates 3 – 5 clinical trials per year in the National Institutes of Health (NIH) Clinical Center. The CTP also maintains and oversees collaborations and contracts with academic institutions, biotechnology and pharmaceutical companies, and nonprofit organizations who evaluate VRC products.

The CTP/VRC is soliciting applications for two staff clinician (physician) positions to serve as a principal or associate investigator of phase 1 trials evaluating vaccines or monoclonal antibodies against a variety of infectious diseases. The staff clinician will work closely with the CTP chief and other VRC staff in clinical trial design, protocol development, clinical trial operations, and oversight.

Specific responsibilities include the following:

  • Design and implement clinical research for VRC
  • Serve as an associate or principal investigator for VRC clinical trials
  • Conduct and provide oversight for vaccine and monoclonal antibody clinical trials
  • Design, conduct, and analyze data from clinical and translational vaccine immunology research
  • Participate in a variety of meetings with the VRC’s clinical development teams
  • Present VRC research findings publicly (domestically and internationally)
  • Develop and write manuscripts of VRC clinical research findings
  • Participate as a team member, cochair, or chair of domestic and international protocol/clinical trial teams involving VRC study products
  • Serve as a member on NIH and external committees and boards as assigned by VRC
  • Mentor junior scientists and clinicians, including clinical fellows


The applicant must meet the following requirements:

  • M.D. or D.O. and hold an active, unrestricted medical license in the United States
  • Board certification in Internal Medicine and Allergy and Immunology or Infectious Diseases (other Internal Medicine specialty training will be considered)
  • Meet the requirements for credentialing to practice as a staff physician in the NIH Clinical Center
  • Excellent written and verbal communication skills

The ideal candidate will have experience in clinical research. Salary is dependent on experience and accomplishments.

To Apply

Send a letter describing your interest in this position and long-term goals along with a curriculum vitae (CV) to NIAIDVRCPCSS@niaid.nih.gov.

Appointees may be US citizens or resident aliens. Applications from women, persons from underrepresented groups, and persons with disabilities are strongly encouraged. This position is subject to a background check. Applications will be accepted until the position is filled.

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